6-21-56 p1

Esther M. Zimmer Lederberg
Gender Discrimination: Martha Chase

MarthaChase

Alfred Hershey and Martha Chase were working on their well known "blender experiment." Their experiments were on a bacterial virus made of DNA and protein, using radioactive phosphate to track the DNA and radioactive sulfur to track the protein, and they found that only the DNA, and not much protein, entered the infected cells. This confirmed that the genes must be DNA. They concluded that DNA was the hereditary material in viruses. Martha Chase was a lab technician under Hershey at the Carnegie Institute of Washington. Alfred Hershey was awarded the Nobel Prize in Medicine in 1962 for his work in "discoveries concerning the replication mechanism and the genetic structure of viruses". However, many people believe that as in the past, the Nobel committee displayed gender discrimination as Chase was not recognized (she was working as a lab assistant at the time). Alfred Hershey did not mention Martha Chase in his Nobel Lecture, "Idiosyncrasies of DNA Structure," in 1969. However, the experiment will always be referred to as the "Hershey-Chase Experiment".

Hershey, A. D. and M. Chase. "Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage." Journal of General Physics. 36.1 (1952): 39-56.

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